Halothane (fluothane) - the chemical approach to non-explosive volatile anaesthetic agents
نویسندگان
چکیده
منابع مشابه
Clinical experience with fluothane, a new non-explosive anaesthetic agent.
FoR ~ANY YEARS anaesthetists have felt the need for a non-explosive anaesthetic agent possessing none of the. disadvantages assocmted with chloroform, trichlorethylene and mtrous o~ide, rhat is, the agent should be non-hepatotoxm, stable in the presence of soda lime and heat, an~ have a high therapeu :ie ratio. Since most heavily fluorinated hydrocarbons are not m2qamma )le, and many possess an...
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15 صفحه اولStructural changes in dividing sea-urchin eggs induced by the volatile anaesthetic halothane.
Fertilized Lytechinus eggs exposed to the volatile anaesthetic halothane before metaphase do not undergo cytoplasmic cleavage. This effect has been correlated with the failure of the contractile ring to assemble. Comparative studies on mitotic apparatuses isolated from control and halothane-treated cells show that halothane significantly impairs both spindle and aster growth as early as metapha...
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We used constant potential in vivo voltammetry to measure changes in striatal ascorbate in the rat in response to i.p. administration of several non-volatile anaesthetics. Propofol and pentobarbitone, which enhance GABA-mediated neuronal inhibitions, decreased ascorbate current to 27.0 (SEM 7.4) % and 46 (6) % of control, respectively. Chloral hydrate, diazepam alone or with ketamine, and fenta...
متن کاملAdverse reactions to anaesthetic agents.
Sir,—Even though some small changes in heart rate were shown to be statistically significant, no clinical significance was attached to such changes. The study was primarily done to assess the overall need of anticholinergic premedication in patients undergoing minor surgery and as such drugs were not administered on a weight basis. However, Dr Gilmour's comment has aroused our interest in this ...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1958
ISSN: 0003-2409
DOI: 10.1111/j.1365-2044.1958.tb08060.x